All times are shown in CET (Central European Time).
8:50 - 9:00 CET OPENING and WELCOME to Session 1
9:00 - 10:20 CET Session 1: Indian GPCR Community
Chairs: Hemlata Agnihotri (University of Delhi, India) and Shanu Jain (Indian Institute of Technology, Kanpur, India)
9:00 - 9:20 Arun Shukla (Indian Institute of Technology, Kanpur):
Molecular basis of naturally-encoded signaling-bias at seven transmembrane receptors
9:20 - 9:40 Vidita Vaidya (Tata Institute of Fundamental Research, Mumbai):
Serotonergic Psychedelics - Mapping their anxiolytic actions
9:40 - 10:00 Prem N Yadav (Central Drug Research Institute, Lucknow):
TGR5 Signalling in Neural Stem Cell Homeostasis: Implication in Ageing Associated CNS disorders.
10:00 - 10:20 Kasturi Pal (Ashoka University, Haryana):
Sugar coating adhesion GPCRs: Dissecting the roles of N-glycosylation in ADGRG6 maturation and signalling
10:20 - 10:30 CET Flash Talks 1:
Anandhu J (Ashoka University)
Sangita Bhattacharyya (The University of Kansas medical Center)
Miguel Dieguez (Hospital del Mar Research Institute)
Infant Sagayaraj Ravhe (Indian Institute of Technology)
Esther Montoliu (Instituto de Química Médica, IQM - CSIC)
10:30 - 11:00 CET Poster Session 1: Discussion with presenters in individual breakout rooms:
1.1. Amit Sudhakar Naglekar, 1.2. Anandhu J., 1.3. Sangita Bhattacharyya, 1.4. Miguel Dieguez, 1.5. Infant Sagayaraj Ravhe, 1.6. Esther Montoliu, 1.7. Søren Norge Andreassen
BREAK
11:55 - 12:00 CET WELCOME Session 2
12:00 - 13:20 CET Session 2: Advancing GPCR Discovery: A Journey of Academia–Industry Collaboration
Chair: Maria Majellaro (Celtarys Research S.L., Santiago de Compostela, Spain)
12:00 - 12:20 Maria Majellaro (Celtarys, Spain):
A game-changing technology to Illuminate GPCR pharmacology: accelerating hit discovery & optimization
12:20 - 12:40 Ago Rinken (University of Tartu, Estonia):
Lipid Nanoparticles Displaying GPCRs: A Versatile Platform for Ligand Binding Studies
12:40 - 13:00 Jorge Barbazán (Oncomet, Health Research Institute of Santiago de Compostela, Spain):
Imaging adenosine receptors in colorectal cancer using innovative fluorescence ligands
13:00 - 13:20 Prashant Donthamsetti (University of Vanderbilt, Tennessee, USA):
Optical Control of Dopamine Receptors
13:20 - 13:30 CET Flash Talks 2:
13:30 - 14:00 CET Poster Session 2: Discussion with presenters in individual breakout rooms (30 min)
2.1. Icaro A. Simon , 2.2. Shivani Sachdev, 2.3. Rosa M. Mella, 2.4. Sandeepa Dey, 2.5. Toni Capó Quetglas, 2.6. Jonas Mühle, 2.7. Fabio Francavilla
8:55 - 9:00 CET WELCOME Session 3
9:00 - 10:20 CET Session 3: The Australian and New Zealand GPCR Community
Chair: Sarah Piper (Monash University, Australia)
9:00 - 9:20 Debbie Hay (University of Otago, New Zealand):
Targeting the class B GPCR receptorome by understanding their ligands, splice variants, accessory proteins and signalling
9:20 - 9:40 Alisa Glukhova (Walter and Eliza Hall Institute of Medical Research , Melbourne, Australia):
Using cryo-electron microscopy to understand the biology and drug binding of the Wnt signalling pathway
9:45 - 10:00 Shane Hellyer (Monash Institute of Pharmaceutical Sciences, Melbourne, Australia):
Dissecting the subcellular complexity of mGlu5 signalling
10:00 - 10:10 Nicola Smith (Department of Pharmacology, School of Biomedical Sciences at University of New South Wales, Sydney, Australia):
Identifying novel targets for the treatment for lung adenocarcinoma
10:10 - 10:20 Jianjun Cao (Monash Institute of Pharmaceutical Sciences, Melbourne, Australia):
Structure Meets Design: Advancing Our Understanding of CGRP Receptors
10:20 - 10:30 CET Flash Talks 3:
10:30 - 11:00 CET Poster Session 3: Discussion with presenters in individual breakout rooms (30 min)
3.1. Anni Allikalt, 3.2. Anne Madariaga, 3.3. Adam Wright, 3.4. Francesco Fontanive, 3.5. Arianna Migliorini, 3.6. Oscar Díaz Sanzo, 3.7. Elizaveta Korchevaya
BREAK
11:55 - 12:00 CET WELCOME Session 4
12:00 - 13:20 CET Session 4: ECIs of the GPCR FORUM Community
Chair: Aida Shahraki (Institute of Pharmaceutical Chemistry, Philipps University Marburg, Germany) and Itziar Muneta Arrate (University of Geneva, Switzerland)
Poster prize winners of the 1st GPCR Forum Conference presenting 10 min talks
Friederike Marlene Wunsch (Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Germany)
Dynamics shaping GPCRs’ functionality
Florian Boessl (Leibniz Institute for Food Systems Biology, Technical University of Munich, Germany)
Decoding Odorant Receptor Activation: Integrating Simulation and Sequence-Driven Approaches to Understand OR Function
Tomasz Maciej Stepniewski (Hospital del Mar Research Institute, Barcelona, Spain, and InterAx Biotech, Switzerland)
Computational modeling of arrestin preactivation reveals insights into an intermediate conformational state
Marta López Balastegui (Hospital del Mar Research Institute, Barcelona, Spain)
Integrating AI-based predictive algorithms and GPCR-specific features for accurate genetic variant impact prediction
Judith Alenfelder (University of Bonn, Germany):
Chemogenetic G protein-ligand pairs for causal investigation of cellular biology in vitro and in vivo
Adrián García Recio (Hospital del Mar Research Institute, Barcelona, Spain)
GPCRmd: A Dynamic Platform for Exploring GPCR Structural and Functional Landscapes
13:20 - 13:30 CET Flash Talks 4:
13:30 - 14:00 CET Poster Session 4: Discussion with presenters in individual breakout rooms (30 min)
4.1. Gáspár Pándy-Szekeres, 4.2. Shravan Rathod, 4.3. Marc Ciruela Jardí, 4.4. Javier Sanchez Lorente, 4.5. Evgenii Ziaikin, 4.6. Alejandro Peralta Garcia, 4.7. Arman Simonyan
12:55 - 13:00 CET WELCOME Session 5
13:00 - 14:10 CET Session 5: GPCR Ladies
Chairs: Masha Niv (The Hebrew University of Jerusalem, Israel) and Silvia Sposini (Imperial College London, UK, and Interdisciplinary Institute for Neuroscience, Bordeaux, France)
13:00 - 13:05 Opening Remarks
13:05 - 13:25 Arisbel Batista Gondin (Monash Institute of Pharmaceutical Sciences, Australia):
Allosteric modulation of opioid receptors: unlocking new pathways to pain relief
13:25 - 13:50 Mette Rosenkilde (Copenhagen University, Denmark):
Unlocking the potential of GPCRs: paving the way for future therapeutics
13:50 - 14:10 Moran Shalev Benami (Weizmann Institute of Science, Israel):
Structure in early and evolved organisms: Can 7TM ancestors reveal a missing link in GPCR signaling?
14:20 - 14:30 CET Flash Talks 5:
14:30 - 15:00 CET Poster Session 5: Discussion with presenters in individual breakout rooms (30 min)
5.1. Roberta Cristofalo, 5.2. Paulina Dragan, 5.3. Sema Alzubaidi, 5.4. Bahram Khashin, 5.5. Chloé Weckel, 5.6. Margaux Bilay, 5.7. Antoniel A. S. Gomes
BREAK
16:55 - 17:00 CET WELCOME Session 6
17:00 - 19:00 CET Session 6: University of California San Francisco - GPCR Research
Chair: Aashish Manglik (University of California San Francisco, USA)
17:00 - 17:20 Federica Liccardo (UCSF Cardiovascular Research Institute, USA):
Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist
17:20 - 17:40 Xinyu Xu (University of California San Francisco, USA):
Random Background for Ligand Optimization
17:40 - 18:00 Nicole Fisher (University of California San Francisco, USA):
Spatiotemporal dynamics of G protein activation by opioid receptors
18:00 - 18:20 Matthew K Howard (University of California San Francisco, USA):
Deep mutational scanning to understand GPCR function and pharmacology
18:20 - 18:30 CET Flash Talks 6:
18:30 - 19:00 CET Poster Session 6: Discussion with presenters in individual breakout rooms (30 min)
6.1. Luca Franchini 6.2. Dylan Capitti Fenton, 6.3. Simone Aureli, 6.4. Alvaro Caceres, 6.5. Berkay Selcuk, 6.6. Claudia Garrigós, 6.7. Joan Biel Rebassa Palou
19:00 - 19:15 CET Poster Prizes & Closing
END of MEETING