Session 1: Oncornet 2.0

View Session 1

Séverine Chaumont-Dubel (IGF, Montpellier, France): Novel signalling mechanisms associated with CXCR4 and ACKR3: lessons from interactomics

Géraldine Schlecht-Louf (Université Paris-Saclay, France): Role of ACKR3 to skin homeostasis

Stephanie Anbuhl (QVQ, The Netherlands): Nanobodies and conjugates, detecting, modulating and targeting CXCR4

Dehan Comez (University of Nottingham, UK): The effect of ligand and nanobody binding dynamics on EGFR/CXCR4 complex (10min)

Noureldine Youssef (Universitätsklinikum Jena, Germany): Characterization of distinct GRK requirements and β-arrestin2 conformational changes induced by natural and synthetic ACKR3 agonists (10min)

Session 2: Adhesion

View Session 2

Tobias Langenahn (University of Leipzig, Germany): How Adhesion G protein coupled receptors came to be

Ines Liebscher (University of Leipzig, Germany): Fantastic adhesion GPCRs and how to target them

Xian Piao (University of California, San Francisco, USA): ADGRG1/GPR56 and the brain:  One molecule and multiple functions

Sumit Bandekar (Postdoctoral Fellow, Arac Lab, University of Chicago, USA): Structural basis for regulation of CELSR1 by a compact module in its extracellular region

Stephanie Häfner (AG Scholz, (University of Leipzig, Germany): Advancing Drug Discovery for Human Adhesion GPCRs:  The NTF Release Sensor Approach

Session 3:  COMPARE

View Session 3

Caroline Gorvin (University of Birmingham, UK):  Insights into accessory protein modulation of metabolic GPCR activity  (not recorded)

Rob Lane (University of Nottingham, UK):  Harnessing kinetics to target the dopamine and opioid receptors (not recorded)

Simon Platt (University of Nottingham, UK):  Development of a ligand directed fluorescent label for the adenosine A3 receptor with retained orthosteric binding site accessibility  (not recorded)

Shannon O’Brien (University of Birmingham, UK):  Spatio-temporal control of G protein-coupled receptor activity: Investigating FFAR4 signalling in adipocytes 

Dan Nieves (University of Nottingham, UK):  Mapping membrane order nano-environments using SMLM 

Session 4: 

The Canadian GPCR Community

View Session 4

Shane Wright (Karolinska Institutet, Sweden): Harnessing biased signalling for safer anti-diabetes/obesity drugs (not recorded)

Louis-Philippe Picard (University of Toronto, Canada): Conformational Dynamics Driving G Protein Selectivity in A2A Receptor Signaling

Terry Hebert (McGill, Québec, Canada): Combining induced pluripotent stem cells and biosensors for GPCR-based drug discovery

Etienne Billard (McGill, Québec, Canada): Toward deciphering functional selectivity at 5-HT2A receptors

Ana Lilia Moreno Salinas (Université de Sherbrooke, Québec, Canada): Characterizing hADGRE5/CD97 Activation and Signaling by Mechanical Stimulation 

Session 5: i-GPCRnet

View Part 1

Stephen Hill (University of Nottingham, UK): New fluorescent probes to study endogenous adenosine receptors

Ralf Jockers (Institut Cochin, Paris, France): Identification of natural Glp1R variants: just the beginning of the journey (not recorded)

Martin Lohse (ISAR Biosciences, Munich, Germany): Receptor signaling at the nanometer scale

Raphael Silvanus Haider (University of Nottingham, Nottingham, UK): The impact of individual GPCR domains on β-arrestin conformational changes and functionality

Bernard Masri (Institut Cochin - INSERM U1016, Paris, France): Identification of surrogate ligands for the atypical orphan GPCR, GPR50 (not recorded)

View Part 2

Juliette Gourdon (INRAE, Tours, France): Highly specific nanobodies acting as powerful allosteric modulators for the human follicle-stimulating hormone receptor

Léo Bonhomme (CBS2, Université de Montpellier, France): 3-color single-molecule FRET reveals GPCR concerted conformational changes

Marta Cimadevila (IGF, CNRS, Montpellier, France): Internalization of mGlu heterodimers

Session 6: Arising GPCRers in China

View Part 1

Guodong He (Tsinghua University, Beijing, China): A Sustained Signaling Induced by GPCR-G protein-β-arrestin Megacomplex (not recorded)

Wenqing Shui (ShanghaiTech University, Beijing, China): Post-translational modifications orchestrate the intrinsic signaling bias of an orphan GPCR

Jia Duan (Chinese Academy of Sciences, Beijing, China): GPCR activation and GRK2 assembly by a biased intracellular agonist

Guangyi Lan (School of Life Sciences, Peking University, China): Progesterone sulfates induce itch and enable early prediction of cholestasis in pregnancy (not recorded)

View Part 2

Zeming Qiu (National institute of Biological Sciences, Beijing, China): Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling

Yue Wang (Chinese Academy of Sciences, China): The molecular basis of opioid receptors activated by opioid peptides