PROGRAM
DAY 1 - Monday, November 25, 2024
14:00 - 16:20 CET
Session 1: ONCORNET2.0 (ONCOgenic GPCR Network of Excellence and Training)
Role and modulation of canonical and atypical chemokine receptors
Chair: Martine Smit Vrije Universiteit Amsterdam, Department of Chemistry and Pharmaceutical Sciences, The Netherlands
Introduction ONCORNET consortium
14:05 - 14:25 Séverine Chaumont-Dubel (IGF, Montpellier, France):
Novel signalling mechanisms associated with CXCR4 and ACKR3: lessons from interactomics
14:30 - 14:55 Géraldine Schlecht-Louf (Université Paris-Saclay, France):
Advances in ONCORNET2.0, a lever to shed light on the role of ACKR3 in skin physiology
15:00 - 15:10 Stephanie Anbuhl (QVQ, The Netherlands):
Nanobodies and conjugates, detecting, modulating and targeting CXCR4
15:13 - 15:23 Dehan Comez (University of Nottingham, UK):
The effect of ligand and nanobody binding dynamics on EGFR/CXCR4 complex
15:26 - 15:36 Noureldine Youssef (Universitätsklinikum Jena, Germany):
Characterization of distinct GRK requirements and β-arrestin2 conformational changes induced by natural and synthetic ACKR3 agonists
15:40 - 15:50 CET
Flash Talks 1: Yao Yao 1.1., Noureldine Youssef 1.2., Maria Majellaro 1.3., Noemi Karsai 1.4., Bert Beerkens 1.5.
15:50 - 16:20 CET
Poster Session 1: Discussion with presenters in individual breakout rooms (30 min)
Yao Yao 1.1., Noureldine Youssef 1.2., Maria Majellaro 1.3., Noemi Karsai 1.4., Bert Beerkens 1.5., Friederike Wunsch 1.6. , Paulina Dragan 1.7.,
Sadaf Dadashkhan 1.8.
BREAK
17:00 - 19:20 CET
Session 2: ADHESION GPCR Consortium (AGC)
Chairs: Nicole Scholz University of Leipzig, Rudolf Schönheimer Institute of Biochemistry, Scholz Lab, Germany, Nathan Zaidman University of New Mexico, Biochemistry & Molecular Biology, USA
17:00 - 17:25 Tobias Langenhan (Leipzig University, Germany): How Adhesion G protein coupled receptors came to be
17:25 - 17:50 Ines Liebscher (Leipzig University, Germany): Fantastic adhesion GPCRs and how to target them
17:50 - 18:15 Xianhua Piao (University of California, San Francisco, USA): ADGRG1/GPR56 and the brain: One molecule and multiple functions
18:15 - 18:28 Sumit Bandekar (Postdoctoral Fellow, Arac Lab, University of Chicago, USA): Structural basis for regulation of CELSR1 by a compact module in its extracellular region
18:28 - 18:40 Stephanie Häfner (Postdoc, Joint Member of the Scholz and Langenhan Labs, Leipzig University, Germany): Advancing Drug Discovery for Human Adhesion GPCRs: The NTF Release Sensor Approach
18:40 -18:50
Flash Talks 2: Petra Ferjan 2.1., Francesco Ferri 2.2., Marc Ciruela Jardí 2.3., Wijnand van der Velden 2.4.
18:50 - 19:20
Poster Session 2: Discussion with presenters in individual breakout rooms (30 min)
Petra Ferjan 2.1., Francesco Ferri 2.2., Marc Ciruela Jardí 2.3., Wijnand van der Velden 2.4., Florian Bößl 2.5., Jaume Lillo 2.6.,
Camilla Guccione 2.7.
DAY 2 - Tuesday, November 26, 2024
14:00 - 16:20 CET (13:00 - 15:20 BST)
Session 3: COMPARE - The Centre of Membrane Proteins and Receptors (UK)
Chair: Davide Calebiro University of Birmingham, Institute of Metabolism and Systems Research, Department of Metabolism and Systems Science, UK
Introduction
14:00 - 14:20 Caroline Gorvin (University of Birmingham, UK): Insights into accessory protein modulation of metabolic GPCR activity (20 min)
14:25 - 14:45 Rob Lane (University of Nottingham, UK): Harnessing kinetics to target the dopamine and opioid receptors (20 min)
14:50 - 15:00 Simon Platt (University of Nottingham, UK):
Development of a ligand directed fluorescent label for the adenosine A3 receptor with retained orthosteric binding site accessibility (10 min)
15:03 - 15:13 Shannon O’Brien (University of Birmingham, UK):
Spatio-temporal control of G protein-coupled receptor activity: Investigating FFAR4 signalling in adipocytes (10 min)
15:15 - 15:40 Daniel Nieves (University of Birmingham, UK): Mapping membrane order nano-environments using SMLM (20 min)
15:40 - 15:50
Flash Talks 3: Thomas Tarenzi 3.1., Kristoffer Sahlholm 3.2., Maris-Johanna Tahk 3.3., Ramilya Murtazina 3.4., Matteo Pavan 3.5., Tomasz Stepniewski 3.6.
15:50 - 16:20
Poster Session 3: Discussion with presenters in individual breakout rooms (30 min)
Thomas Tarenzi 3.1., Kristoffer Sahlholm 3.2., Maris-Johanna Tahk 3.3., Ramilya Murtazina 3.4., Matteo Pavan 3.5., Tomasz Stepniewski 3.6.,
Julie Delaroche 3.7., Marija Popović-Nikolić 3.8.
BREAK
17:00 - 19:20 CET (11:00 - 13:20 EST)
Session 4: The Canadian GPCR Community
Chair: Stephane Laporte Division of Endocrinology and Metabolism, Department of Medicine, McGill, Québec, Canada
17:00 - 17:20 Shane Wright (Karolinska Institutet, Sweden):
Harnessing biased signalling for safer anti-diabetes/obesity drugs
17:25 - 17:45 Louis-Philippe Picard (University of Toronto, Canada):
Conformational Dynamics Driving G Protein Selectivity in A2A Receptor Signaling
17:50 - 18:10 Terry Hebert (McGill, Québec, Canada):
Combining induced pluripotent stem cells and biosensors for GPCR-based drug discovery
18:15 - 18:25 Etienne Billard (McGill, Québec, Canada):
Toward deciphering functional selectivity at 5-HT2A receptors
18:27 - 18:37 Ana Lilia Moreno Salinas (Université de Sherbrooke, Québec, Canada):
Characterizing hADGRE5/CD97 Activation and Signaling by Mechanical Stimulation
18:40 - 18:50
Flash Talks 4: Clizia Russotto 4.1., Francesco Fontanive 4.2., Aleix Quintana 4.3., Marta López Balastegui 4.4., Alejandro Peralta-García 4.5.
18:50 - 19:20
Poster Session 4: Discussion with presenters in individual breakout rooms (30 min)
Clizia Russotto 4.1., Francesco Fontanive 4.2., Aleix Quintana 4.3., Marta López Balastegui 4.4., Alejandro Peralta-García 4.5., Paola Oliva 4.6., Anna Grimm 4.7., Marija Čarapić 4.8
DAY 3 - Wednesday, November 27, 2024
9:00 - 11:40 am CET
Session 5: i-GPCRnet - International Research Network (IRN) on GPCRs
Chairs: Ralf Jockers (Institute Cochin, Paris, France), Xavier Iturrioz (INSERM CEA SiMoS, France)
9:00 - 9:20 Stephen Hill (University of Nottingham, UK): New fluorescent probes to study endogenous adenosine receptors
9:25 - 9:45 Ralf Jockers (Institut Cochin, Paris, France): Identification of natural Glp1R variants: just the beginning of the journey
9:50 - 10:10 Martin Lohse (ISAR Biosciences, Munich, Germany): Receptor signaling at the nanometer scale
10:15 - 10:25 Raphael Silvanus Haider (University of Nottingham, Nottingham, UK):
The impact of individual GPCR domains on β-arrestin conformational changes and functionality
10:28 - 10:38 Bernard Masri (Institut Cochin - INSERM U1016, Paris, France): Identification of surrogate ligands for the atypical orphan GPCR, GPR50
10:40 - 10:50 Juliette Gourdon (INRAE, Tours, France):
Highly specific nanobodies acting as powerful allosteric modulators for the human follicle-stimulating hormone receptor
10:52 - 11:02 Robert B. Quast (Centre de Biologie Structurale, Montpellier, France):
3-color single-molecule FRET reveals GPCR concerted conformational changes
11:05 - 11:15 Marta Cimadevila (IGF, CNRS, Montpellier, France): Internalization of mGlu heterodimers
11:20 - 11:30
Flash Talks 5: Berta Carrasco Martinez 5.1., Shubham Vishnoi 5.2., Judith Alenfelder 5.3., Lucía González-Pico 5.4., Owen Underwood 5.5.
11:30 - 12:00
Poster Session 5: Discussion with presenters in individual breakout rooms (30 min)
Berta Carrasco Martinez 5.1., Shubham Vishnoi 5.2., Judith Alenfelder 5.3., Lucía González-Pico 5.4., Owen Underwood 5.5., Joan Biel Rebassa Palou 5.6., Estefanía Moreno 5.7., Cristian Lombo 5.8.
BREAK
13:00 - 15:40 CET (20:00 - 22:40 CST)
Session 6: Arising GPCRers in China
Chairs: Jiafei Mao (Institute of Chemistry, Chinese Academy of Sciences, Beijing, China), Sanduo Zheng (National Institute of Biological Sciences, Beijing, China), Xiangyu Liu (School of Pharmaceutical Sciences, Tsinghua University, Beijing, China)
13:00 - 13:15 Guodong He (School of Pharmaceutical Sciences, Tsinghua University, Beijing, China):
A Sustained Signaling Induced by GPCR-G protein-β-arrestin Megacomplex
13:20 - 13:35 Wenqing Shui (iHuman Institute & School of Life Science and Technology, ShanghaiTech University, China):
Post-translational modifications orchestrate the intrinsic signaling bias of an orphan GPCR
13:40 - 13:55 Jia Duan (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Beijing, China):
GPCR activation and GRK2 assembly by a biased intracellular agonist
14:00 - 14:15 Guangyi Lan (School of Life Sciences, Peking University, China):
Progesterone sulfates induce itch and enable early prediction of cholestasis in pregnancy
14:20 - 14:35 Zeming Qiu (National Institute of Biological Sciences, Beijing, China):
Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling
14:40 - 14:55 Yue Wang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Beijing, China):
The molecular basis of opioid receptors activated by opioid peptides
15:00-15:10
Flash Talks 6: Adrián García Recio 6.1., Charlotte Crauwels 6.2., Hongyue Liu 6.3., Anna Chorianopoulou 6.4., David Shi 6.5
15:10-15:40
Poster Session 6: Discussion with presenters in individual breakout rooms (30 min)
Adrián García Recio 6.1., Charlotte Crauwels 6.2., Hongyue Liu 6.3., Anna Chorianopoulou 6.4., David Shi 6.5., David Aranda 6.6., Shanshan Li 6.7.
Antonio Capó Quetglas 6.8.
END of MEETING