PROGRAM

DAY 1 - Monday, November 25, 2024

14:00 - 16:20 CET

Session 1: ONCORNET2.0 (ONCOgenic GPCR Network of Excellence and Training) 

Role and modulation of canonical and atypical chemokine receptors 

Chair: Martine Smit  Vrije Universiteit Amsterdam, Department of Chemistry and Pharmaceutical Sciences, The Netherlands

Introduction ONCORNET consortium

14:05 - 14:25 Séverine Chaumont-Dubel (IGF, Montpellier, France): 

Novel signalling mechanisms associated with CXCR4 and ACKR3: lessons from interactomics

14:30 - 14:55 Géraldine Schlecht-Louf (Université Paris-Saclay, France): 

Advances in ONCORNET2.0, a lever to shed light on the role of ACKR3 in skin physiology


15:00 - 15:10 Stephanie Anbuhl (QVQ, The Netherlands): 

Nanobodies and conjugates, detecting, modulating and targeting CXCR4

15:13 - 15:23 Dehan Comez (University of Nottingham, UK): 

The effect of ligand and nanobody binding dynamics on EGFR/CXCR4 complex

15:26 - 15:36 Noureldine Youssef (Universitätsklinikum Jena, Germany): 

Characterization of distinct GRK requirements and β-arrestin2 conformational changes induced by natural and synthetic ACKR3 agonists

15:40 - 15:50 CET

Flash Talks 1: Yao Yao 1.1., Noureldine Youssef 1.2., Maria Majellaro 1.3., Noemi Karsai 1.4., Bert Beerkens 1.5.

15:50 - 16:20 CET

Poster Session 1:  Discussion with presenters in individual breakout rooms (30 min)

Yao Yao 1.1., Noureldine Youssef 1.2., Maria Majellaro 1.3., Noemi Karsai 1.4.,  Bert Beerkens 1.5., Friederike Wunsch 1.6. , Paulina Dragan 1.7.,  

Sadaf Dadashkhan 1.8.


BREAK


17:00 - 19:20 CET

Session 2: ADHESION GPCR Consortium (AGC)

Chairs: Nicole Scholz  University of Leipzig, Rudolf Schönheimer Institute of Biochemistry, Scholz Lab, Germany, Nathan Zaidman University of New Mexico, Biochemistry & Molecular Biology, USA


17:00 - 17:25 Tobias Langenhan (Leipzig University, Germany):  How Adhesion G protein coupled receptors came to be

17:25 - 17:50 Ines Liebscher (Leipzig University, Germany): Fantastic adhesion GPCRs and how to target them

17:50 - 18:15 Xianhua Piao (University of California, San Francisco, USA):  ADGRG1/GPR56 and the brain: One molecule and multiple functions 


18:15 - 18:28 Sumit Bandekar (Postdoctoral Fellow, Arac Lab, University of Chicago, USA):  Structural basis for regulation of CELSR1 by a compact module in its extracellular region

18:28 - 18:40 Stephanie Häfner (Postdoc, Joint Member of the Scholz and Langenhan Labs, Leipzig University, Germany):  Advancing Drug Discovery for Human Adhesion GPCRs: The NTF Release Sensor Approach


18:40 -18:50

Flash Talks 2: Petra Ferjan 2.1., Francesco Ferri 2.2., Marc Ciruela Jardí 2.3., Wijnand van der Velden 2.4.

18:50 - 19:20

Poster Session 2Discussion with presenters in individual breakout rooms (30 min)

Petra Ferjan 2.1., Francesco Ferri 2.2., Marc Ciruela Jardí 2.3., Wijnand van der Velden 2.4., Florian Bößl 2.5.,  Jaume Lillo 2.6.,

Camilla Guccione 2.7.

DAY 2 - Tuesday, November 26, 2024


14:00 - 16:20 CET (13:00 - 15:20 BST)

Session 3: COMPARE  - The Centre of Membrane Proteins and Receptors (UK)

Chair: Davide Calebiro University of Birmingham, Institute of Metabolism and Systems Research,  Department of Metabolism and Systems Science, UK

Introduction 

14:00 - 14:20 Caroline Gorvin (University of Birmingham, UK): Insights into accessory protein modulation of metabolic GPCR activity  (20 min)

14:25 - 14:45 Rob Lane (University of Nottingham, UK): Harnessing kinetics to target the dopamine and opioid receptors  (20 min)


14:50 - 15:00 Simon Platt (University of Nottingham, UK): 

Development of a ligand directed fluorescent label for the adenosine A3 receptor with retained orthosteric binding site accessibility (10 min)

15:03 - 15:13 Shannon O’Brien (University of Birmingham, UK): 

Spatio-temporal control of G protein-coupled receptor activity: Investigating FFAR4 signalling in adipocytes (10 min)

15:15 - 15:40 Daniel Nieves (University of Birmingham, UK): Mapping membrane order nano-environments using SMLM (20 min)


15:40 - 15:50

Flash Talks 3: Thomas Tarenzi 3.1., Kristoffer Sahlholm 3.2., Maris-Johanna Tahk 3.3., Ramilya Murtazina 3.4., Matteo Pavan 3.5., Tomasz Stepniewski 3.6.

15:50 - 16:20

Poster Session 3: Discussion with presenters in individual breakout rooms (30 min) 

Thomas Tarenzi 3.1., Kristoffer Sahlholm 3.2., Maris-Johanna Tahk 3.3., Ramilya Murtazina 3.4., Matteo Pavan 3.5., Tomasz Stepniewski 3.6., 

Julie Delaroche 3.7., Marija Popović-Nikolić 3.8.


BREAK


17:00 - 19:20 CET (11:00 - 13:20 EST)

Session 4: The Canadian GPCR Community

Chair:  Stephane Laporte  Division of Endocrinology and Metabolism, Department of Medicine, McGill, Québec, Canada


17:00 - 17:20 Shane Wright (Karolinska Institutet, Sweden): 

Harnessing biased signalling for safer anti-diabetes/obesity drugs

17:25 - 17:45 Louis-Philippe Picard (University of Toronto, Canada): 

Conformational Dynamics Driving G Protein Selectivity in A2A Receptor Signaling

17:50 - 18:10 Terry Hebert (McGill, Québec, Canada): 

Combining induced pluripotent stem cells and biosensors for GPCR-based drug discovery


18:15 - 18:25 Etienne Billard (McGill, Québec, Canada): 

Toward deciphering functional selectivity at 5-HT2A receptors 

18:27 - 18:37 Ana Lilia Moreno Salinas (Université de Sherbrooke, Québec, Canada): 

Characterizing hADGRE5/CD97 Activation and Signaling by Mechanical Stimulation 


18:40 - 18:50

Flash Talks 4: Clizia Russotto 4.1., Francesco Fontanive 4.2., Aleix Quintana 4.3., Marta López Balastegui 4.4., Alejandro Peralta-García 4.5.

18:50 - 19:20

Poster Session 4: Discussion with presenters in individual breakout rooms (30 min) 

Clizia Russotto 4.1., Francesco Fontanive 4.2., Aleix Quintana 4.3., Marta López Balastegui 4.4., Alejandro Peralta-García 4.5., Paola Oliva 4.6., Anna Grimm 4.7., Marija Čarapić 4.8


DAY 3 - Wednesday, November 27, 2024


9:00 - 11:40 am CET

Session 5: i-GPCRnet - International Research Network (IRN) on GPCRs

Chairs: Ralf Jockers (Institute Cochin, Paris, France), Xavier Iturrioz (INSERM CEA SiMoS, France)



9:00 - 9:20 Stephen Hill (University of Nottingham, UK):  New fluorescent probes to study endogenous adenosine receptors


9:25 - 9:45 Ralf Jockers (Institut Cochin, Paris, France): Identification of natural Glp1R variants: just the beginning of the journey


9:50 - 10:10 Martin Lohse (ISAR Biosciences, Munich, Germany): Receptor signaling at the nanometer scale



10:15 - 10:25 Raphael Silvanus Haider (University of Nottingham, Nottingham, UK): 

The impact of individual GPCR domains on β-arrestin conformational changes and functionality


10:28 - 10:38 Bernard Masri (Institut Cochin - INSERM U1016, Paris, France): Identification of surrogate ligands for the atypical orphan GPCR, GPR50


10:40 - 10:50 Juliette Gourdon (INRAE, Tours, France): 

Highly specific nanobodies acting as powerful allosteric modulators for the human follicle-stimulating hormone receptor


10:52 - 11:02 Robert B. Quast (Centre de Biologie Structurale, Montpellier, France): 

3-color single-molecule FRET reveals GPCR concerted conformational changes


11:05 - 11:15 Marta Cimadevila (IGF, CNRS, Montpellier, France): Internalization of mGlu heterodimers



11:20 - 11:30

Flash Talks 5: Berta Carrasco Martinez 5.1., Shubham Vishnoi 5.2., Judith Alenfelder 5.3., Lucía González-Pico 5.4., Owen Underwood 5.5.

11:30 - 12:00

Poster Session 5: Discussion with presenters in individual breakout rooms (30 min) 

Berta Carrasco Martinez 5.1., Shubham Vishnoi 5.2., Judith Alenfelder 5.3., Lucía González-Pico 5.4., Owen Underwood 5.5., Joan Biel Rebassa Palou 5.6., Estefanía Moreno 5.7., Cristian Lombo 5.8.


BREAK


13:00 - 15:40 CET (20:00 - 22:40 CST)

Session 6: Arising GPCRers in China

Chairs:  Jiafei Mao (Institute of Chemistry, Chinese Academy of Sciences, Beijing, China),  Sanduo Zheng (National Institute of Biological Sciences, Beijing, China), Xiangyu Liu (School of Pharmaceutical Sciences, Tsinghua University, Beijing, China)


13:00 - 13:15 Guodong He (School of Pharmaceutical Sciences, Tsinghua University, Beijing, China): 

A Sustained Signaling Induced by GPCR-G protein-β-arrestin Megacomplex

13:20 - 13:35 Wenqing Shui (iHuman Institute & School of Life Science and Technology, ShanghaiTech University, China): 

Post-translational modifications orchestrate the intrinsic signaling bias of an orphan GPCR

13:40 - 13:55 Jia Duan (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Beijing, China): 

GPCR activation and GRK2 assembly by a biased intracellular agonist

14:00 - 14:15 Guangyi Lan (School of Life Sciences, Peking University, China): 

Progesterone sulfates induce itch and enable early prediction of cholestasis in pregnancy

14:20 - 14:35 Zeming Qiu (National Institute of Biological Sciences, Beijing, China): 

Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling

14:40 - 14:55 Yue Wang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Beijing, China): 

The molecular basis of opioid receptors activated by opioid peptides


15:00-15:10

Flash Talks 6: Adrián García Recio 6.1., Charlotte Crauwels 6.2., Hongyue Liu 6.3., Anna Chorianopoulou 6.4., David Shi 6.5

15:10-15:40

Poster Session 6: Discussion with presenters in individual breakout rooms (30 min)

Adrián García Recio 6.1., Charlotte Crauwels 6.2., Hongyue Liu 6.3., Anna Chorianopoulou 6.4., David Shi 6.5., David Aranda 6.6., Shanshan Li 6.7.

Antonio Capó Quetglas 6.8.



END of MEETING

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